Bloodrot Pox

At the beginning of your end phase, destroy this, then it deals 2 damage to you unless you pay

This triggers and resolves in the end phase. There is no priority and it can not be responded to.
This triggered effect resolves before choosing an arsenal card, putting pitched cards on the bottom of your deck, and drawing up to your intellect.
If there are two or more effects that trigger in the end phase, the turn player decides the order that those layers resolve.
Effects that increase costs to play cards or activate abilities do not alter the cost to prevent the damage from this effect.